Gut issues are more common than many of us want to admit.  In fact, one recent survey showed that ~50% of Americans suffer from some sort of gut issues, including being diagnosed with such or suspected. (Reference: https://oshihealth.com/lets-talk-poop-survey/)

One key factor that is often overlooked is how stress affects the gut.  When stress levels rise, cortisol increases, which can slow gut motility, contribute to bloating and constipation, and trigger reflux or digestive discomfort.

Gut Essentials is designed to interrupt this cycle from both directions:

• Supports stress response and serotonin activity with Digexin®—a patent-pending and synergistic blend of Okra (Abelmoschus esculentus) and Ashwagandha (Withania somnifera) shown to help regulate cortisol
• Rebalances the gut microbiome with a heat-resilient, clinically studied probiotic strain (Bacillus coagulans SNZ 1969)
• Calms inflammation and strengthens the gut barrier with antioxidant-rich lingonberry extract

Digexin® has been evaluated in two well-controlled (ie, randomized, double-blind, placebo-controlled) clinical trials involving men and women aged 25–60 with chronic constipation.

Study Design:  The first study was 14 days, while the 2nd lasted 60 days, with both clinical trials used the exact same 300g dose of Digexin found in each daily serving of Gut Essentials.

Clinical Results: The two well-controlled clinical trials found that supplementing with 300mg Digexin® once daily provided the following health benefits:

• Significantly restored normal bowel functions by significantly reducing common constipation-related symptoms, including discomfort, pain, cramps, and bloating over 90%—
• Significantly improved bowel regularity, with participants more than doubling the # of bowel movements they experienced each week, increasing from an average less than  bowel movements per week to over 6 per week.
• Maintained consistently reduced bloating, minimizing abdominal swelling associated with gas and air retention
• Improved sleep quality while reducing reported stress and anxiety, even increasing how a person feels much better when they wake up in the morning.
• Not surprisingly, all the beneficial effects lead to a nearly doubling of a person’s quality of life (QOL)
• Works in as little as 7 days (and possibly faster but that was when the first assessments were made in both of the clinical trials), although the longer one ingested the Digexin, the greater the benefits. To be more specific, and to manage expectations, Digexin reduced symptoms of constipation 35% after just 7 days, 78% after 14 days, 81% after 30 days and 93% after 60 days.  In fact, in one of the studies, 88% of the participants were free from constipation after just 14d.

How does Digexin work?

• Significantly reduced cortisol levels, supporting a healthier stress response regulation
  
• Improved gut hormone levels such as gastrin levels*, which support healthy gastric acid release which is essential for healthy digestion, as well as increasing serotonin levels, which is associated with an improved mood and a positive gut–brain signaling
• Significantly increased serum diamine oxidase (DAO), which is an enzyme that metabolizes histamine which can cause some GI issues in certain individuals

Significantly improved gut barrier integrity by reducing leaky gut  

Bacillus coagulans SNZ 1969 is a proprietary, spore-based probiotic designed to survive harsh stomach acid and reach the intestines intact—where it can deliver targeted digestive support. Unlike traditional probiotics that are sensitive to heat as well as being degraded in the acidic stomach, this resilient strain remains stable and active reaching the lower part of gut where it can exert its beneficial effects

In Gut Essentials, B. coagulans SNZ 1969
supports:

• Rebalancing of the gut microbiome by promoting beneficial bacteria
• Improved gut motility, supporting relief from constipation and irregularity
• Strengthening of the gut barrier, helping reduce intestinal permeability (“leaky gut”) and enhance nutrient absorption

Clinical Studies:

·       There are over a dozen human clinical trials demonstrating the beneficial effects ofBacillus coagulans SNZ 1969 supplementation, making it is one of the most well-researched probiotic there is demonstrating both  a strong safety and efficacy profile.

·       Doses used in the clinical trials ranged from 500 million CFU (Colony Forming Units) to 2 billion CFU.

·       Each daily serving of Gut Essentials provides 2 billion CFU of Bacillus coagulans SNZ 1969.

•  One well-controlled (Randomized, Double-Blind, Placebo-Controlled) clinical trial investigated the effects of Bacillus coagulans SNZ 1969 (1 billion CFU/d) for 60 days in 92 individuals  with two subtypes of irritable bowel syndrome—IBS with constipation (IBS-C) and IBS with diarrhea (IBS-D with the following beneficial effects [1]: Significantly reduced GI symptoms in both IBS-C and IBS-D groups compared to placebo
• Resulted in beneficial responses in 90% of IBS-C patients and 100% of IBS-D patients, compared to no responders in the placebo group (p <0.0001)
• Significantly improved quality-of-life (QOL) across both IBS subtypes compared to placebo, which produced no change in QOL

In another well-controlled clinical trial, 60 individuals with GI discomfort were given 2b CFU of Bacillus coagulans SNZ 1969 daily
or placebo for 30d with the following beneficial effects (and all significantly
greater than that seen in the placebo group) :[2]

• Significant reduction in total GI symptoms
• Significant reduction in pain intensity
• Significantly greater satisfaction
• With beneficial effects being seen at least 7d after discontinuation of SNZ 1969

This Nordic superfruit is packed with polyphenols and antioxidants to calm the gut and combat inflammation. Traditionally foraged across the Nordics, lingonberry supports microbiome diversity, digestion, and everyday vitality.

A review focused on the effects of lingonberry fruit phenolic compounds in human in vitro cells and in vivo clinical studies. Studies with lingonberries, lingonberry juice/lingonberry nectar/fermented lingonberry juice, and phenolic fractions with active molecules were reviewed. 

Lingonberry’s bioactive substances have a diverse range of antimicrobial, anti-inflammatory, antiproteolytic, and antioxidant properties. Fermentation of lingonberries and modulation of the dysbiotic microbiome to a more symbiotic composition by favoring the growth of lactobacilli and inhibiting the growth of human opportunistic pathogens were discussed. 

This review provided an overview of those studies published so far on the effects of lingonberry phenolic substances on humans in vitro and in vivo. The composition of lingonberry fruits has been studied extensively. The phenolic bioactive molecules have multiple beneficial effects on cell and clinical levels in humans. The effects seem to be concentration/tested human cell type or microbial strain dependent, often showing synergistic activity.